Menopause and Your Heart
Menopause and Heart Health: What Women Need to Know
Menopause is a natural and inevitable process that marks the end of a woman's reproductive years. It typically occurs between the ages of 45 to 55, and is defined as the permanent cessation of menstrual periods for at least 12 months. Menopause affects every woman differently, but it can also have a significant impact on cardiovascular health.
The Role of Estrogen and the Heart
Estrogen is a hormone that plays a significant role in heart health. Before menopause, estrogen helps protect against heart disease by decreasing the levels of “bad” LDL cholesterol and increasing the levels of “good” HDL cholesterol. Estrogen also helps keep blood vessels flexible and assists with maintaining healthy blood pressure levels. However, during menopause, estrogen levels decrease, which can lead to changes in cholesterol levels, blood pressure fluctuations, and an increased risk of heart disease.
Possible Heart-Related Symptoms
During menopause, both women and their healthcare providers should take note of potential symptoms of heart disease. These may include chest pain or discomfort, fatigue, shortness of breath, or heart palpitations. However, women may also experience atypical or non-specific symptoms such as fatigue, sleep disturbances, and joint pain, which may be overlooked as indicators of heart disease.
Reasons Why Cholesterol and Blood Pressure Increase
During menopause, women may experience unfavorable changes in cholesterol levels and blood pressure. One reason for cholesterol increases is lower estrogen levels, as mentioned earlier. Blood vessel walls can thicken and become less elastic, which can cause high blood pressure. Additionally, other risk factors for heart disease, such as diabetes, smoking, and obesity, become more common with age, which can amplify the impact of menopausal changes on cardiovascular health.
Underestimation of Risk
Women frequently underestimate the heart disease risk and delay seeking medical care for symptoms. This underestimation may be exacerbated by the atypical symptoms mentioned earlier that can be mistaken for other conditions. Women and their healthcare providers should be aware of these potential signs and ensure that regular check-ups and risk assessments are completed.
HRT and Heart Disease
Hormone replacement therapy (HRT) has been used to help alleviate menopause symptoms for many years, but its relationship to heart disease risk has been the subject of some debate. The Women’s Health Initiative (WHI) study in the early 2000s found an increased risk of heart disease and stroke in women using combined estrogen and progestin hormone therapy.
Recent academic studies have refuted this earlier conclusion and suggested that HRT may be beneficial to the heart if taken when used appropriately and timed correctly. For example, a 2017 study published in Menopause, the journal of the North American Menopause Society, suggested that women who start HRT within 10 years of menopause may reduce their long-term risk of dying from heart disease.
In conclusion, menopause can impact women's heart health in various ways, due to changes in cholesterol levels, blood pressure, and other risk factors. Women should not underestimate their risk of heart disease, and healthcare providers should also be vigilant and aware of atypical symptoms. Hormone replacement therapy carries some risks but may also benefit cardiovascular health if taken correctly, further supporting the importance of regular, personalized healthcare for women during and after menopause.
Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women’s Health Initiative randomized controlled trial. JAMA. 2002 Jul 17;288(3):321–33.
Hodis HN, Mack WJ. Menopausal Hormone Replacement Therapy and Reduction of All-Cause Mortality and Cardiovascular Disease: It Is About Time and Timing. Cancer J. 2022 Jun 1;28(3):208–23.
Schierbeck LL, Rejnmark L, Tofteng CL, Stilgren L, Eiken P, Mosekilde L, et al. Effect of hormone replacement therapy on cardiovascular events in recently postmenopausal women: randomised trial. BMJ. 2012 Oct 9;345:e6409.
Nudy M, Chinchilli VM, Foy AJ. A systematic review and meta-regression analysis to examine the “timing hypothesis” of hormone replacement therapy on mortality, coronary heart disease, and stroke. Int J Cardiol Heart Vasc. 2019 Mar;22:123–31.
Mirkin S, Amadio JM, Bernick BA, Pickar JH, Archer DF. 17β-Estradiol and natural progesterone for menopausal hormone therapy: REPLENISH phase 3 study design of a combination capsule and evidence review. Maturitas. 2015 May;81(1):28–35.